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Isotretinoin is generally effective, though some patients may need to use systemic corticosteroids, either concomitant with or just before isotretinoin. In a common condition like acne, psoriasis or skin cancer, it might be worth the risks. Keep in touch using your doctor particularly when he has prescribed strong medicines. Certain antibiotics really should not be taken by women who are pregnant or breast feeding, as it can impact bone and teeth continuing development of a fetus or infant. g tacrolimus and pimecrolimus), intralesional injections of triamcinolone, mycophenolate mofetil, cyclosporine, and isotretinoin, to note a few. ) Adapalene cream and gel formulations were significantly less irritating compared to the tretinoin formulations and not significantly more irritating than petrolatum. Moreover, for any hassle-free treatment, it includes a relatively long effect, usually including four to six months. 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